p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.
نویسندگان
چکیده
منابع مشابه
p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain.
We have previously reported that wild-type p53 can bind single-stranded (ss) DNA ends and catalyze renaturation of ss complementary DNA molecules. Here we demonstrate that p53 can also bind to internal segments of ss DNA molecules via a binding site (internal DNA site) distinct from the binding site for DNA ends (DNA end site). Using p53 deletion mutants, the internal DNA site was mapped to the...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1994
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.91.1.413